productdatasheet

RecombinantHumanSERPINH1(Hsp47)

ORDERINGINFORMATION

Formulation:Sterile-filteredcolorlesssolution(1mg/ml)in20mMTris-HCl,pH8.0,and10%glycerol.Purifiedbyproprietarychromatographictechniques.

BACKGROUND

SERPINH1isamemberoftheserpinsuperfamilyofserineproteinaseinhibitorswhoseexpressionisinducedbyheatshock.Asamolecularchaperone,itlocalizestotheendoplasmicreticulumlumenandbindscollagen,thusparticipatinginthematurationofcollagenmolecules,facilitatingthefoldingandassemblyofprocollagenmolecules,retainingunfoldedmoleculeswithintheER,andassistinginthetransportofcorrectlyfoldedmoleculesfromtheERtotheGolgiapparatus.AutoantibodiestoSERPINH1havebeenfoundincasesofrheumatoidarthritis.

DESCRIPTION

RecombinanthumanSERPINH1producedinE.coliisasingle,non-glycosylatedpolypeptidecontaining439aminoacids(aa18-417)withamolecularweightof48.9kDa.Itisfusedtoa37-aminoacidHis-tagattheN-terminus.

SPECIFICATIONSUMMARY

CatalogNumber	Size
11125P-10	10ug
11125P-50	50ug
11125P-1000	1000ug

CatalogNumber	Size
11125P-10	10ug
11125P-50	50ug
11125P-1000	1000ug

Source:EscherichiacoliPurity:Greaterthan90%asdeterminedbySDS-PAGE.Accessionnumber:P50454Aminoacidsequence:

RGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSHMAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL.

STORAGEANDSTABILITY

Storeat4oCifentirevialwillbeusedwithin2-4weeks.Storeatorbelow-20oCforlongerperiodsoftime.Additionofacarrierprotein(suchas0.1%HSAorBSA)isrecommendedforlong-termstorage.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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