Recombinant Human Myelin Oligodendrocyte Glycoprotein (MOG)

Catalog Number	Size
24202P-10	10ug
24202P-50	50ug
24202P-1000	1000ug

Catalog Number	Size
24202P-10	10ug
24202P-50	50ug
24202P-1000	1000ug

ORDERING INFORMATION

Formulation: Solution of Myelin Oligodendrocyte Glycoprotein (0.5mg/ml) was lyophilized from 20mM sodium acetate buffer, pH 4.0, and 0.3M sodium chloride.BACKGROUND

Myelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Given its localization, it is a prime target antigen of immune-mediated demyelination. MOG is involved in completion and maintenance of the myelin sheath and in cell-cell communication.

MOG is differentially expressed in the dorsolateral prefrontal cortex and in the temporal lobe from patients with schizophrenia.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

DESCRIPTION

Recombinant Human MOG produced in

E. coli is a single non-glycosylated polypeptide chain containing 132 amino acids with a molecular weight of 15.2kDa. It is fused to a 6X His-tag

at the C-terminus.

Amino Acid Sequence:

Met-GQFRVIGPRHPIRALVGDEVE LPCRISPGKNATGMEVGWYR PPFSRVVHLYRNGKDQDGDQ APEYRGRTELLKDAIGEGKV TLRIRNVRFSDEGGFTCFFR DHSYQEEAAM ELKVEDPFYWVSPG- HHHHHH

Purity: Greater than 95% as determined by SDS- PAGE and RP-HPLC.Accession number: Q16653

SOLUBILITY

Reconstitute lyophilized MOG in sterile 10mM acetic acid to no less than 100ug/ml which can be further diluted in other aqueous solutions as needed.

STORAGE AND STABILITY

Although stable at room temperature for 3 weeks, the lyophilized product is best stored at or below -20oC. Upon reconstitution, MOG can be stored at 4oC for up to 1 week but is best stored at or below -20oC for longer periods of time.

Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long- term storage.

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