ORDERINGINFORMATION
Catalognos.:13002P-2020ug13002P-100100ug13002P-10001000ugFormulation:Lyophilizedfromasterile-filteredsolution(1mg/ml)inPBS,pH7.4Purifiedbyproprietarychromatographictechniques.BACKGROUND
Cu/ZnSuperoxideDismutase(SOD1)catalyzesthereactionbetweensuperoxideanionsandhydrogentoyieldmolecularoxygenandhydrogenperoxide.Itprotectsacellfromdangerouslevelsofsuperoxide.SOD1bindscopperandzincionsandisoneofthreeisozymesresponsIBLefordestroyingfreesuperoxiderADIcals.MutationsinSOD1causeaformoffamilialamyotrophiclateralsclerosis(ALS).
DESCRIPTION
RecombinantHumanCu/ZnSOD1producedinE.coliisahomodimernon-glycosylatedpolypeptidechaincontaining2x154aminoacidswithamolecularweightof31.6kDa.
SPECIFICATIONSUMMARY
Source:EscherichiacoliPurity:Greaterthan95%asdeterminedbySDS-PAGEandRP-HPLC.Accessionnumber:P00441.2Aminoacidsequence:MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
SOLUBILITY
ReconstitutelyophilizedproductinsteriledistilledH2Otonolessthan100ug/mlwhichcanbefurtherdilutedinotheraqueoussolutionsasneeded.
BIOLOGICALACTIVITY
Potencypermgis10,000units/mgasdeterminedbythePyrogallicAcidmethod.
STORAGEANDSTABILITY
Althoughlyophilizedproductisstableatroomtemperaturefor3weeks,itisbeststoredatorbelow-20oC.Afterreconstitution,productshouldbestoredatorbelow-20oC.Additionofacarrierprotein(0.1%HSAorBSA)isrecommendedforlong-termstorage.
Forinvitroinvestigationaluseonly.Notintendedforuseintherapeuticordiagnosticprocedures.
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