CalnexinMonoclonalAntibody

ORDERINGINFORMATIONCatalogNo.:90007(cloneC2A1)Format:100ug,ProteinA-purified,lyophilized,0.1MTris,0.1Mglycine,2%sucrose,1mg/ml.

BACKGROUND

Calnexinisa~90kDaintegralproteinoftheendoplasmicreticulum;itisalsoreferredtoasIP90,p88andp90.Itconsistsofa50kDaN-terminalcalcium-bindingluminaldomain,asingletransmembranehelix,and

ashortacidiccytoplasmictail.Itspositivelychargedcytosolicresiduesensureitsretentionintheendoplasmicreticulum.Calnexintogetherwithcalreticulinplayakeyroleinglycoproteinfoldingbyinteracting

withfoldingintermediatesviatheirmonoglycosylatedglycans.CalnexinhasalsobeenshowntoassociatewiththemajorhistocompatABIlitycomplexclassIheavychains,partialcomplexesoftheTcellreceptor,andBcellsurfaceimmunoglobulin.

SPECIFICATIONSUMMARYAntigen:DictyosteliumdiscoideumAX2recombinantfragment.Accessionno.P27824.Hostspecies:Mouse.AntibodyClass:IgG1.Preservative:None.SPECIFICITY

Thisantibodyreactswithhumanand

Dictyosteliumdiscoideumcalnexin.

APPLICATIONS

Immunoblotting:useat1-10ug/ml.

Immunohistochemistry:useat1-10ug/ml.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

RECONSTITUTION

Reconstituteindistilledwater.

STORAGEANDSTABILITY

Thisproductisstableforatleastone(1)yearat-20oCto-70oC.Reconstitutedproductshouldbestoredinappropriatealiquotstoavoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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