MMP9MetalloproteinaseMonoclonalAntibody

ORDERINGINFORMATION

CatalogNo.:29022(cloneS51-82)Size:100uginPBS(1mg/ml),pH7.4,50%glycerol,0.09%sodiumazide.

PurifiedbyProteinGaffinitychromatography.

BACKGROUND

MMP9isinvolvedinthebreakdownofextracellularmatrixinembryonicdevelopment,reproduction,woundhealing,andtissueremodelingaswellasindiseaseprocessessuchasarthiritisandmetastasis.Oncesynthesized,MMPsexistaslatentproenzymes.MaximumMMPactivityrequiresproteolyticcleavageoftheproenzymetogenerateactiveMMPbyreleasingtheinhibitorypropeptidedomainfromthefull-lengthprotein.

SPECIFICATIONSUMMARY

Antigen:Fusionproteincorrespondingtoaa1-708(full-length)ofratMMP9(accessionno.NP_112317).

HostSpecies:Mouse

AntibodyClass:IgG2a

SPECIFICITY

Thisantibodyrecognizeshuman,mouse,andratMMP9.

APPLICATIONS

Immunoblotting:useat1-2ug/ml.Bandsof

~92and82kDa(proenzymeandactiveenzyme)aredetected.

Adultratbrainimmunoblot

Immunohistochemistry:useat1-5ug/ml.Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

Positivecontrol:ratbrainlysate.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisproductisstableforatleast1yearat

-20oC.Freezeinmultiplealiquotstoavoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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