productdatasheet

Anti-Cavβ2Ca+2ChannelMonoclonalAntibody

ORDERINGINFORMATION

CatalogNo.:11524(cloneS8b-1)Size:100uginPBS,pH7.4;50%

glycerol,0.09%sodiumazide.PurifiedbyProteinGaffinitychromatography.

BACKGROUND

IonchannelsareintegralmembraneproteinsthathelpestablishandcontrolthesmallvoltagegrADIentacrosstheplasmamembraneoflivingcellsbyallowingtheflowofionsdowntheirelectRochemicalgradient.Cavβsubunitsareinvolvedinthetransportofthepore-formingalpha1subunittotheplasmamembrane.TheyalsoshieldanERRetentionsignalonthealpha1subunit,therebyguidingthepore-formingsubunittothetargetmembrane.

SPECIFICATIONSUMMARY

Antigen:Syntheticpeptidecorrespondingtoaa189-205ofratCavβ2(RSPKPSANSVTSPHSKE)(accessionno.NP_446303).

HostSpecies:Mouse

AntibodyClass:IgG1

SPECIFICITY

Thisantibodyrecognizeshuman,mouse,andratCavβ2.Itdoesnotcross-reactwithCavβ1,Cavβ3,orCavβ4.

APPLICATIONS

Immunoblotting:useat1-10ug/ml.Abandof~78kDaisdetected.

AdultratbrainlysateImmunohistochemistryandImmunocytochemistry:useat0.1-1ug/mlImmunofluorescence:useat1-10ug/ml

Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.

Positivecontrol:Ratbrainlysate

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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SanDiego,CA92127

TollFree800.929.2114

Phone858.675.2405

Fax858.592.1509

info@qedbio.com

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