GonadotropinReleasingHormone(GnRH,LHRH)MonoclonalAntibodies

ORDERINGINFORMATION

CatalogNo.CloneNo.MAbSubtypeSize				LibraryPackNo.100ug/clone
19301	LHRH13-327.8	IgG1	100ug,500ug	193101	All4clones
19302	LHRH13-372.14	IgG1	100ug,500ug
19303	LHRH13-387.5	IgG1	100ug,500ug
19304	LHRH13-426.12	IgG1	100ug,500ug

Format:ProteinG-purifiedantibodyinPBS,pH7.4.

BACKGROUND

Gonadotropin-releasinghormone(GnRH),alsoknownasluteinizinghormone-releasinghormone(LHRH),isa10aminoacidneurohormoneproducedinthehypothalamus.GnRHstimulatesthesynthesisandsecretionofthetwogonadotropins—luteinizinghormone(LH)andfollicle-stimulatinghormone(FSH)—bytheanteriorpituitarygland.Characteristicofallreleasinghormones,andmoststrikinginthecaseofGnRH,isthephenomenonofpulsatilesecretion.

Undernormalcircumstances,GnRHisreleasedinpulsesatintervalsofabout90to120minutes.AbnormalitiesinthepulsatilesecretionofGnRHresultinsubnormalfertilityandabnormalorabsentmenstruation.ConstantadmiNISTrationofGnRHsuppressesgonadotropinsecretion,whichhastherapeuticbenefitsincertainpatients,suchaschildrenwithprecociouspubertyandmenwithprostatecancer.

SPECIFICATIONSUMMARY

Antigen:Purifiedhumangonadotropinreleasinghormone.

HostSpecies:Mouse

Specificity:TheseantibodiesrecognizehumanGnRH.

APPLICATIONS

TheseantibodieshavebeenqualifiedforuseinELISA,immunohistochemistry,andRIAtodetecthumanGnRH.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.

RIA

CatalogNo.ngGnRHfor50%MAb

Displacement

193011.10

193022.70

193038.85

1930411.30

ImmunofluorescentdetectionofmouseGnRHneuronalcellswith#19304(Rajendren,GandGibson,MJ2001JNeuroendocrinology13:270).

DILUTIONINSTRUCTIONS

DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Theseantibodiesarestableforatleastone(1)yearat-20oCto-70oC.Storeproductinappropriatealiquotstoavoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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