productdatasheet

InsulinReceptorMonoclonalAntibodiesORDERINGINFORMATION

CatalogNo.:50101,50102,50103,50104.

Size:100ugProteinG-purifiedantibodyinPBS,pH7.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

SPECIFICATIONSUMMARYSTORAGEANDSTABILITY

Antigen:50101,50102,50103:IM-9Theseantibodiesarestableforatleastlymphocytes.50104:humanplacentalone(1)yearat-20oCto-70oC.

insulinreceptor.Storeproductinappropriatealiquotstoavoidmultiplefreeze-thawcycles

HostSpecies:Mouse.

AntibodyClass:50101=IgG2a;REFERENCES

50102,50103=IgG1;50104=IgG2bSoosetal.(1986)BiochemJ235:199;

Stabilizers:NoneBrindleetal.(1990)BiochemJ268:Preservatives:None.Availableon615;Prigentetal.(1990)JBiolChemrequest.265:9970.

SPECIFICITY

Allfourclonesrecognizethehumaninsulinreceptor;low-levelofcross-reactivitywithbovineandrabbitinsulinreceptor.

Conc.forhalf-maximaleffect(nM)

SubunitCat.No.Specificity	%InhibitionofInsulinBindingIM-9ADIpocytes	BIOLOGicalInhibitionof ActivityInsulinBinding	StimulationofLipogenesis
50101(83-14)α	8090	Insulin-like0.05	0.01
50102(83-7)?	010	Insulin-like-	1.0
50103(47-9)α	9298	Inhibitsinsulin0.2	-
50104(18-44)β	3540	Insulin-like0.2	0.3

APPLICATIONS

Cat.No. 50101(83-14)	Immunoprecipitation +++	WesternBlot -	ReceptorKinaseAssay Activatesreceptorkinase
50102(83-7)	+	-	Activatesreceptorkinase
50103(47-9)	-	-	Blocksactivationbyinsulin
50104(18-44)	+	+	Activatesreceptorkinase

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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