productdatasheet

IGF-1ReceptorMonoclonalAntibodies

ORDERINGINFORMATION

CatalogNo.:35101,35102,35103

Size:100ugProteinG-purifiedantibodyinPBS,pH7.4

SPECIFICATIONSUMMARY

Antigen:PurifiedhumanplacentalIGF-1receptors.

HostSpecies:MouseAntibodyClass:IgG1StABIlizers:None

Preservatives:None.Availableonrequest.

SPECIFICITY

AllthreeclonesarespecificforthehumanIGF-1receptor;35102and35103recognizetheαsubunit:

• 35101(3B7)stimulatesbindingofIGF-1and-2;stimulatesbasalandIGF-1stimulatedcellgrowth.

• 35102(1H7)inhibitsbindingofIGF-1and-2;inhibitscellgrowth.

• 35103(2C8)hasnoeffectonbindingofIGF-1or-2.

APPLICATIONS

UsetheseantibodiesinresearchstudiestodelineatesignaltransductionpathwaysspecificforIGF’sandfordetectingIGF-1receptorsincrudesamples.35101maybeusedtoimmunoprecipitateIGF-1receptors.35102and35103canrecognizetheIGF-1αsubunitonimmunoblots.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Theseantibodiesarestableforatleastone(1)yearat-20oCto-70oC.Storeproductinappropriatealiquotstoavoidmultiplefreeze-thawcycles.

REFERENCE

Xiongetal.(1992)ProcNatlAcadSciUSA89:5356;Lietal.(1993)Biochem

BiophysResCommun196:92.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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