ORDERINGINFORMATION
CatalogNo.:56270(cloneLy1C6)
Format:100uginPBS,pH7.4,purifiedbyProteinGaffinitychromatography,0.09%sodiumazide,50%glycerol.
BACKGROUND
Lysosome-associatedmembraneproteins(LAMP1andLAMP2)aremajorconstituentsofthelysosomalmembrane.Thestructuresofthesetwoproteinsarecloselyrelatedwith37%sequencehomology.Botharetransmembraneglycoproteinslocalizedprimarilyinlysosomesandlateendosomes.CellsurfaceLAMP1andLAMP2promoteadhesionofhumanperipheralbloodmononuclearcells(PBMC)tovascularendotheliumwhichsuggeststhattheyareinvolvedinadhesionofPBMCatsitesofinflammation.
SPECIFICATIONSUMMARY
Antigen:Ratliverlysosomemembranes.
HostSpecies:Mouse
AntibodyClass:IgG1
Specificity:Thisantibodyrecognizeshuman,rat,andhamsterLAMP1.
Accessionno.:NP_036989.1GeneID:25328
APPLICATIONS
Immunoblotting:Useat1ug/ml.Abandof
~120kDaisdetected.
Immunocytochemistry:Useat5-10ug/ml.
LAMP1detectedinratlivermicrosomes.ImmunofluorescentdetectionofLAMP1in
transfectedHeLacells.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplication.
DILUTIONINSTRUCTIONS
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
STORAGEANDSTABILITY
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
REFERENCE
LewisVetal.1985.JCellBiol100:1839-1847.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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