Anti-TRICK2(DR5,TRAIL-R2)Antibody

ORDERINGINFORMATION

CatalogNo.:11091

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.

BACKGROUND

ApoptosisisinducedbycytokinesintheTNFfamilythroughtheirdeathdomaincontainingreceptors.TRICK2(TRAILreceptorinducerofcellkilling2)isamemberoftheTNFreceptorfamilyandcontainstheconserveddeathdomain.TRICK2isexpressedathighlevelsinlymphocytesandspleencellsandinmanytypesoftumorcells.OverexpressionofTRICK2rapidlyinducescelldeathbyapoptosis.TRICK2hasbeenshowntofunctionasareceptorforTRAILandcaninhibitTRAIL-inducedkillingoflymphocyticcells.OthernamesforTRICK2includeDR5,Apo2,TRAIL-R2,andKILLER.

SPECIFICATIONSUMMARY

Immunogen:Syntheticpeptidecorrespondingtoaminoacids409-427(LGERLAKQKIEDHLLSSGK,isoform1)of

humanTRICK2precursorconjugatedtoKLHattheN-terminus.Thesamesequence

isfoundataminoacids380-398inisoform2.

HostSpecies:Rabbit

StABIlizers:None

Preservatives:None.Availableonrequest.

SPECIFICITY

ThisantibodyrecognizeshumanTRICK2.

APPLICATIONS

Immunoblotting:usea1:500dilution.Abandofapproximately57kDaisdetected.

Positivecontrol:wholecelllysatefromHL60,HeLa,orJurkatcells.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

QED Bioscience为您的所有生物学研究需求提供大量定制服务，例如定制抗体生产，细胞培养服务，细胞系开发和细胞库。我们的定制抗体服务包括多克隆和单克隆抗体生产，体外抗体生产和抗体纯化。