Anti-RasAntibody

CatalogNumber	Quantity
11068-50	50ug
11068-200	200ug

CatalogNumber	Quantity
11068-50	50ug
11068-200	200ug

ORDERINGINFORMATION

BACKGROUND

MonomericG-proteinRasfunctionsasamolecularswitchlinkingreceptorandnonreceptortyrosinekinaseactivationtoanumberofdownstreamsignalingpathways.Oncogenicmutations,whichoccurinapproximately30%ofallcasesofhumancancer,leadtothestimulationofproliferationandtheinhibitionofapoptosis.

SPECIFICATIONSUMMARY

Antigen:A13-residuesyntheticpeptidefromtheeffectorbindingloopofH-,K-,andN-Ras,residues31-43(EYDPTIEDSYRKQ((C).

HostSpecies:Rabbit

Format:AffinityPurified

Buffer:PBS,pH7.2,50%glycerol,0.09%sodiumazide.

SPECIFICITY

Thisantibodyrecognizeshuman,mouse,ratandbovineRas.Itdetectsabandof21-23kDabyWesternblot.

APPLICATIONS

Immunoblotting:useat1–4ug/ml.

WesternblotanalysisofRas:Lane1:MWMarker,Lane2:HeLalysate,MouseBrainLysate,RatBrainLysate.

Positivecontrol:HeLacelllysate.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

DILUTIONINSTRUCTIONS

DiluteinPBSormediawhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisproductisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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