Anti-LivinAntibody

ORDERINGINFORMATION

CatalogNo.:11006

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.

BACKGROUND

Apoptosisispreventedbytheinhibitorofapoptosis(IAP)proteins.AnovelmemberintheIAPproteinfamilyhasbeenidentifiedanddesignatedLivinandKIAPforkidneyIAP.Livin/KIAPcontainsasinglebaculoviralIAPrepeat(BIR)domainandaRINGfingerdomainandhastwoisoformstermedLivin-aandLivin-b.TransfectionofLivinincellsresultsinprotectionfromapoptosisinducedbyFADD,BAX,RIP,RIP3andDR6.Livin

hasdirectinteractionwithseveralcaspasesincludingcaspase-3,-7,and-9.Livininhibitstheactivationofcaspase-9inducedbyApaf-1,cytochromec,anddATP.ThetwoisoformsofLivinappeartohavedifferentfunctionsandtissuedistributions.

SPECIFICATIONSUMMARY

Antigen:Peptidecorrespondingtoaa264-280oftheshortformandaa281-298ofthelongformofhumanLivin(accessionno.

NP_071444).

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide

SPECIFICITY

ThisantibodyrecognizeshumanLivin(33kDa).

APPLICATIONS

Immunoblotting:useat0.5-1.0ug/ml.

WesternblotanalysisofLivinexpressioninhumanRajicelllysatewithLivinantibodyat0.5μg/ml.

Positivecontrol:Rajicelllysate.

Immunohistochemistry:useat5ug/ml.

ImmunohistochemicalstainingofLivininhumansmallintestinewithLivinantibodyat5μg/ml.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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