Anti-CAD(CT)Antibody

ORDERINGINFORMATION

CatalogNo.:2416

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.

BACKGROUND

Celldeathsignalsaretransducedbydeathdomain-containingadaptermoleculesandmembersofthecaspasefamilyofproteases.ThesedeathsignalsfinallycausethedegradationofchromosomalDNAbyactivatedDNase.AmouseDNasethatcausesDNAfragmentationwasidentifiedrecentlyanddesignatedCAD(caspaseactivateddeoxyribo-nuclease).ActivationofCAD/DFF40,whichcausesDNAdegradation,isthehallmarkofapoptoticcelldeath.

SPECIFICATIONSUMMARY

Antigen:Peptidecorrespondingtoaa205-222ofmouseCAD(accessionno.O54788).

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

SPECIFICITY

Thisantibodyrecognizesfull-lengthmouseCAD(40kDa).

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

APPLICATIONS

Immunoblotting:useat2ug/ml.

WesternblotanalysisofCADinmousekidneytissuelysatewithCADantibodyat2μg/ml.

Immunohistochemistry:useat2ug/ml.

ImmunohistochemicalstainingofCADinmousekidneytissuewithCADantibodyat2μg/ml.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

Positivecontrol:Mouselungtissuelysate.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

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