Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllVEGF-C,alsoknownasVascularEndothelialGrowthFactorRelatedProtein(VRP),isarecentlydiscoveredVEGFgrowthfactorfamilymemberthatismostcloselyrelatedtoVEGF-D.HumanVEGF-CCDNAencodesapre-pro-proteinof416aminoacidsresidues.ItisalmostidenticaltothemouseVEGF-Cprotein.SimilartoVEGF-D,VEGF-ChasaVEGFhomologydomainspanningthemiddlethirdoftheprecursormoleculeandlongN-andC-terminalextensions.Inadults,VEGF-Cishighlyexpressedinheart,placenta,ovaryandsmallintestine.
RecombinanthumanVEGF-C,lackingtheN-andC-terminalextensionsandcontainingonlythemiddleVEGFhomologydomain,formsprimarilynon-covalentlylinkeddimers.ThisproteinisaligandforbothVEGFR-2/KDRandVEGFR-3/FLT-4.SinceVEGFR-3isstronglyexpressedinlymphaticendothelialcells,ithasbeenpostulatedthatVEGF-Cisinvolvedintheregulationofthegrowthand/ordifferentiationoflymphaticendothelium.AlthoughrecombinanthumanVEGF-Cisalsoamitogenforvascularendothelialcells,itismuchlesspotentthanVEGF-A.Itisalsoapotenttrophicfactorforneuralstemcells. see-doi:10.1038/nn1646.
Note:ThisVEGF-C isfullybiocativeasMeasuredbyitsABIlitytobindtotheVEGFR-3/FLT-4receptorintheBa/F3-hVEGFR-3assay.TheED50inthisassayisabout4ng/mlcorrespondingtoaSpecificActivityof250,000IU/mg.
