Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllRecombinantHumanEndocrineGland-DerivedVascularEndothelialGrowthFactor(EG-hVEGF)isselectivelyexpressedinsteroidogenicglandsandpromotesthegrowthofendocrineglandendothelium.Theidentificationoftissue-selectiveangiogenicfactorsraisesthepossibilitythatothersecretedmoleculesinthisclassexist.Consistentwithsuchanexpressionpattern,thehumanEG-VEGFgenepromoterhasapotentialbindingsiteforsteroidogenicfactor-1,apivotalelementforsteroidogenic-specifictranscription.Inthehumanovary,theexpressionofEG-VEGFistemporallyandspatiallycomplementarytotheexpressionofVEGF-A,bothinthefollicularandinthelutealphase,suggestingcomplementaryandcoordinatedrolesofthesemoleculesinovarianangiogenesis.Also,EG-VEGFexpressioncorrelateswithvascularityinthepolycysticovarysyndrome,aleADIngcauseofinfertility.
Note:ThisEG-hVEGFisfullybio-activeasdeterminedbythedose-dependentstimulationoftheproliferationofhumanumbilicalveinendothelialcells(HUVEC)usingaconcentrationrangeof1.0-5.0ng/ml.
