Neuromics/GDNF/PR29004-100/100 ug

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¥22240.00
货号:PR29004-100
浏览量:127
品牌:Neuromics
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商品描述

Type:Protein

 

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

GDNFpromotesthesurvivalanddifferentiationofdopaminergicneuronsinculture,andisabletopreventapoptosisofmotorneuronsinducedbyaxotomy.Theencodedproteinisprocessedtoamaturesecretedformthatexistsasahomodimer.ThematureformoftheproteinisaligandfortheproductoftheRET(rearrangedduringtransfection)protooncogene.InadditiontothetranscriptencodingGDNF,twoadditionalalternativetranscriptsencodingdistinctproteins,referredtoasastrocyte-derivedtrophicfactors,havealsobeendescribed.MutationsinthisgenemaybeassociatedwithHirschsprungdisease.GDNFenhancessurvivalandmorphologicaldifferentiationofdopaminergicneuronsandincreasestheirhigh-affinitydopamineuptake. 

Note:ThishGDNFisfullyBIOLOGicallyactivewhencomparedtoastandard.TheED50,calculatedbythedose-dependentdopamineuptakeinratmesencephaliccultures,wasfoundtobe4-8ng/ml.

Neuromics很高兴提供精选的Calbindin-1抗体,非常适合在各个领域进行研究。这些经过研究证明的抗体是我们最受欢迎的一些抗体,部分原因是它们的灵活性。我们的Callbindin抗体可用于蛋白质印迹,免疫细胞化学,免疫组织化学和免疫荧光。