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商品描述
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
alphaSynucleinisamemberofafamilyofsmall,highlyconservedproteins,includingsynuclein-alpha,-beta,and-gamma,andsynoretin.Theseproteinsarelocalizedpredominantlyinthebrain,concentratedinpresynapticnerveterminals.Synuclein-alphaisnormallyasolubleprotein.Abnormalsynuclein-alphaformsfilamentousinclusions(LewybodiesandLewyneurites)inseveralneurodegenerativediseases,includingParkinson"sdisease(PD),dementiawithLewybodies,andAlzheimer"sdisease.ItisamajorcomponentofintracellularinclusionsinsporADIcPD.Mutationsinthesynuclein-alphagene(A53TandA30P)havebeenreportedinseveralfamilieswithautosomaldominantParkinsonism.
