

Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllNeurogranin(NRGN)isacalmodulin-bindingproteinwhichisexpressedsolelyinthebrain,mainlyindendriticspines.NRGNisalsotakingpartintheproteinkinaseCsignalingpathwaybybeinga"thirdmessenger"substrateofproteinkinaseC-mediatedmolecularcascadesduringsynapticdevelopmentandremodeling.NRGNbindstocalmodulinintheabsenceofcalcium.NRGNprotein"sphosphorylationbyproteinkinaseClowersitsbindingABIlity.
NRGNHumanRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining101aminoacids(1-78a.a.)andhavingamolecularmassof10.0kDa.NRGNisfusedtoa23aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.