Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllCCL-20isachemotacticfactorthatdrawslymphocytes&neutrophils,ratharthanmonocytes.MIP-3alphainhibitsproliferationofmyeloidProgenitorsincolonyformationassays.MIP3Aplaysaroleintheformationandfunctionofthemucosallymphoidtissuesbyattractinglymphocytesanddendriticcellstowardsepithelialcells.C-terminalprocessedformshavebeenshowntobeequallychemotacticallyactiveforleukocytes.CCL-20holdesantibacterialactivitye.coliATCC25922ands.aureusatcc29213.CCL-20genetranscriptionisactivatedbyH.pylori,whichactivatesNF-kappaBthroughintracellularsignalpathwaywhichinvolvesIkappaBkinaseandNF-kappaB-inducingkinase.MIP-3alphaisinvlovedinchemokine-mediatedlymphocytetraffickingduringgastricinflammationinHelicobacterinfection.CCL-20expressionisinvolvedintherecruitmentofCD45R0-positiveTcellsubsetsintotheintestinallaminapropria.
MIP-3AisinchargeoftheadvancementofpulpalinflammationthroughtherecruitmentofC-CmotifReceptor6-expressinglymphocytesVaginalepithelialcellsrespondtofactorspresentinsemenbysecretingMIP-3alpha,whichincreaseslangerhanscellsrecruitmentduringHIVtransmission.
MIP-3AlphaHumanRecombinantproducedinE.Coliisasingle,non-glycosylated,polypeptidechaincontaining70aminoacidsandhavingamolecularmassof8kDa.TheMIP-3aispurifiedbyproprietarychromatographictechniques.
