Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllKynureninaseisapyridoxal-5-phosphatedependentenzymethatcatalyzesthehydrolyticcleavageoftheaminoacidsL-kynurenineandL-3-hydroxykynureninetogiveeitheranthranilicacidor3-hydroxyanthranilicacidandalanine(1).Theenzymeisamemberofthe“kynureninepathway”enzymes,throughwhichthemajorityofdietarytryptophanisdegradedintheliver,andisinvolvedinthedenovobiosynthesisofNAD+(2,3).Kynureninepathwaygenesareexpressedinimmunesystemcellssuchasmacrophagesandmicroglia.Duringinflammatoryresponses,thekynureninepathwayinthesecellsproducesquinolinicacid(QA)andnotNAD+.QAexcitesneuronsviatheactivationofNMDA(NmethylDaspartate)receptorsresultinginneuronaldamage.ThetissuedamagingprocesshasbeendemonstratedinAIDrelateddementiacomplex,Alzheimer’s,stroke,epilepsy,andHuntington’sdisease.BecauseKynureninaseisoneofthekeyenzymesofQAproduction,itsinhibitorsmaybeusefulforthetreatmentofneurologicaldisorders.TherecombinantKynureninasehasbeenshowntopossessspecificityfor3-hydroxykynurenineoverkynurenine(4,5).
Note:ActivityAssayProtocolonData-sheet
