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商品描述
Type:Protein
SpeciesReactivity:M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllBACE-2isanasparticproteasethatsharessequencesimilaritywithBACE-1,themajorβ-secretaseforgenerationofAβpeptideinneurons.However,BACE-2differsfromBACE-1inseveralaspectsincludingpro-enzymeactivation,substratebindingsites,transcriptionalregulation,andfunctioninAβpeptideproduction.ThedomainstructureofmouseBACE-2consistsofasignalpeptide(aa1-19),pro(aa20-62)andamaturechain(aa63-514)thatconsistsatransmembranedomainandacytoplasmictail.TheC-terminalregion(aa463-514)wasreplacedbyaHistaginthermBACE-2thatalsocontainedaHisresidueatthepositionofTyr357.ThepurifiedrmBACE-2startedatAla63,thesameresidueshownattheN-terminusofthehumanactiveBACE-2.
