Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
OncostatinMisamemberofacytokinefamilythatincludesleukemia-inhibitoryfactor,granulocytecolony-stimulatingfactor,andinterleukin6.Thisgeneencodesagrowthregulatorwhichinhibitstheproliferationofanumberoftumorcelllines.Itregulatescytokineproduction,includingIL-6,G-CSFandGM-CSFfromendothelialcells.
Image:Oncostatin-Mstructureandsequence.
References:
1.OncostatinMGeneTherapyAttenuatesLiverDamageInducedbyDimethylnitrosamineinRats. AmJPathol2007Jul19.
2.TheinflammatorycytokineoncostatinMinducesPAI-1inhumanvascularsmoothmusclecellsinvitroviaPI3kinaseandERK1/2dependentpathways. AmJPhysiolHeartCircPhysiol2007Jun29.
3.MechanismofproteoglycanaggregatedegradationincartilagestimulatedwithoncostatinM. OsteoarthritisCartilage2007Jun15.
4.Interleukin-4antagonizesoncostatinMandtransforminggrowthfactorbeta-inducedresponsesinarticularchondrocytes. JCellBiochem2007Jun1.
5.Vascularendothelialgrowthfactorisinducedbytheinflammatorycytokinesinterleukin-6andoncostatinminhumanADIposetissueinvitroandinmurineadiposetissueinvivo. ArteriosclerThrombVascBiol2007Jul;27(7):1587-95.
6.GainandoverexpressionoftheoncostatinMreceptoroccurfrequentlyincervicalsquamouscellcarcinomaandareassociatedwithadverseclinicaloutcome. JPathol2007Jul;212(3):325-34.
Image:Oncostatin-Mstructureandsequence
