Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
NeuregulinisasignalingproteinforErbB2/ErbB4receptorheterodimersonthecardiacmusclecells,playinganimportantroleinheartstructureandfunctionthroughinducingErbB2/ErbB4receptorphosphorylationandcardiomyocytedifferentiation.Researchonmolecularleveldiscoveredthatneuregulinrecombinantcouldmakedisturbedmyocardialcellstructureintoorderandstrengthentheconnectionbetweenmyocardialcellsbyintercalateddiscsre-organization.Pharmacodynamicexperimentsinanimalsshowedthatneuregulin(NRG1)recombinantcanreducethedegreeofdamageonmyocardialcellscausedbyischemia,hypoxiaandviralinfection..
References:
1.Neuregulin-1enhancesdepolarization-inducedGABArelease. Neuron2007May24;54(4):599-610.
2.Theneuregulin-1receptorerbB4controlsglutamatergicsynapsematurationandplasticity. Neuron2007May24;54(4):583-97.
3.Immunohistochemicalevidenceforimpairedneuregulin-1signalingintheprefrontalcortexinschizophreniaandinunipolardepression. AnnNYAcadSci2007Jan;1096:147-56.
4.Anacuteeffectofneuregulin1betatosuppressalpha7-containingnicotinicacetylcholinereceptorsinhippocampalinterneurons. JNeurosci2006Nov1;26(44):11295-303.
5.Neuregulin1(8p12)andchildhood-onsetschizophrenia:susceptibilityhaplotypesfordiagnosisandbraindevelopmentaltrajectories. MolPsychiatry2007Feb;12(2):195-205.
6.Neuregulin-1/erbB-activationimprovescardiacfunctionandsurvivalinmodelsofischemic,dilated,andviralcardiomyopathy. JAmCollCardiol2006Oct3;48(7):1438-47.
Image: Heregulin-B2structureandsequence
