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商品描述
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllImmunogen:asingle,glycosylated,polypeptidechaincontaining127aminoacidsandhavingamolecularmassof26-32kDa.rhGMCSFdiffersfromthenaturalhumanGM-CSFbyasubstitutionofleucineatposition23(RtoL),andthecarbohydratemoietymaybedifferentfromthenativeprotein.
GMCSFisacytokinethatcontrolstheproduction,differentiation,andfunctionofgranulocytesandmacrophages.Theactiveformoftheproteinisfoundextracellularlyasahomodimer.Thisgenehasbeenlocalizedtoaclusterofrelatedgenesatchromosomeregion5q31,whichisknowntobeassociatedwithinterstitialdeletionsinthe5q-syndromeandacutemyelogenousleukemia.Othergenesintheclusterincludethoseencodinginterleukins4,5,and13.GM-CSFstimulatesthegrowthanddifferentiationofhematopoieticprecursorcellsfromvariouslineages,includinggranulocytes,macrophages,eosinophilsanderythrocytes
