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商品描述
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllTNF-relatedapoptosis-inducingligand(TRAIL)isaligandmoleculewhichinducesapoptosis.ItisatypeIItransmembraneproteinwithhomologytoothermembersofthetumornecrosisfactorfamily.
Inhumans,thegenethatencodesforTRAILislocatedatchromosome3q26.TRAILbindstothedeathreceptors,DR4andDR5.Theprocessofapoptosisiscaspase-8-dependent.Thisproteinpreferentiallyinducesapoptosisintransformedandtumorcells,butdoesnotappeartokillnormalcellsalthoughitisexpressedatasignificantlevelinmostnormaltissues.
