Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllSMAD2ispartoftheSMADfamilyofproteinsthatmediatesignaltransductionbytheTGF-beta/activin/BMP-2/4cytokinesuperfamilyfromreceptorSer/Thrproteinkinasesatthecellsurfacetothenucleus.PhosphorylatedSMAD2isthenabletoformacomplexwithSMAD4orSARA.Thesecomplexesaccumulateinthecellnucleus,wheretheyaredirectlyparticipatingintheregulationofgeneexpression.
SMAD2mediatesthesignaloftheTGF-beta,andthereforeregulatesmultiplecellularprocesses,suchascellproliferation,apoptosis,anddifferentiation.SMAD2isrecruitedtotheTGF-betareceptorsthroughitsinteractionwiththeSMADanchorforreceptoractivation(SARA)protein. TGF-beta1actsonadjacentstromalcellstoturnonSMAD2signallingthatcouldleadtostromaldecidualization.SMAD2isthedownstreamsignaltransducersofTGF-beta-1inhumandentalpulpcells.
