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商品描述
Type:RabbitIgG
Applications:WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:AsyntheticpeptidewithintheN-terminalregion[residues1-100]ofthehumanTREK1protein.[Swiss-Prot#Q9NRT2].
TREK-1isatwo-pore-domainbackgroundpotassiumchannelexpressedthroughoutthecentralnervoussystem.Itisopenedbypolyunsaturatedfattyacidsandlysophospholipids.Aswell,itisregulatedbyvariousneurotransmitters.Ithasbeenshownthatalterationsinthefunctioning,regulation,orbothoftheTREK-1channelmayaltermood.TREK-1isalsoactivatedbyvolatileanestheticsandhasbeensuggestedtobeanimportanttargetintheactionofthesedrugs.Therefore,thisparticularK+channelemergesasapotentialinnovativetargetfordevelopingnewtherapeuticagentsforanesthesiologyandneurology,suchasantidepressants.
Image:DetectionofTREK1inhumanbrainmembranelysate.
