Type:MouseIgG
Applications:E;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:B;H;M;P;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:ProteinGPurified-liquid
Immunogen:NativePGP9.5proteinfrombrain.
PGP9.5isasolublecytoplasmicproteinwithamolecularweightofapproximately25,000kD.Itispresentinneuronsandincellsofthediffuseneuroendocrinesystem.PGP9.5functionsasatissue-specificubiquitincarboxylterminalhydrolaseisoenzyme.ThisenzymeisalsoknownasUCH-L1.Becauseofitsabundanceinnerves,ithasbeenwidelyusedasaMarkerforperipheralnervefibers.
It wasalsodiscoveredasagenemutatedinsomerarefamialformsofParkinson"sdisease.InterestinglyacommonallelicvariantofUCHL1,theS18YpolymorphismisactuallyprotectiveagainstParkinson"sdisease.Itisalsoamarkerfor cellsofthediffuseneuroendocrinesystemandtheirtumors.
CustomerTestimonialandImage:ThePGPmousethatwereceivedfromNeuromicsworksfantastically! Iuseditat1:100withCy3at1:500andgotgreatstainingwithgoodbackgroundlevels.PGP9.5stainingof RatABDominalTissue.CourtesyofJamieNugent(Dr.MarnaEricson"sLab),UniversityofMinnesota.
