Type:RabbitIgG
Applications:IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:M;R;Ze
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:Wholeserum-lyophilized
Immunogen:SyntheticLHRHcoupledtokeyholelimpethemocyanin(KHL)withcarbodiimide(CDI)linker.
LuteinizingHormoneReleasingHormone(LHRH)orGonadotropinReleasingHormone(GnRH)isakeymoleculeintheregulationofreproductioninvertebrates.LHRH,adecapeptide,isproducedbyneuronsinthemedialbasalhypothalamus(MBH)andsecretedinapulsatilemannerintothecardiovascularsystem.ThefrequencyandamplitudeofGnRHpulsesdeterminesecretionoffolliclestimulatinghormone(FSH)andluteinizinghormone(LH)fromthepituitary.Higherfrequencies(greaterthanonepulseperhour)stimulateLHsecretionwhilelowerfrequenciesstimulateFSHsecretion.ThegenerationofGnRHpulsesiseffectedbynumerousstimuli,suchasneural,hormonalandenvironmental.
Image:LHRHstainingofrathypothalamus(medianeminence).
RecentstudiesshowthatGnRHalsohasaroleinmediatingcancer.GnRHhasbeenshowntoinhibitthegrowthofhumanuterineleiomylomacellsbysuppressingproliferationandinducingapoptosis.GnRHanalogshavebeenusedtotreatawidevarietyofreproductivecancers,althoughthesideeffectsofusingsuchcompoundsareoftenquitesevere.
