Type:RabbitIgG
Applications:IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Asyntheticpeptidetoaninternalregion(withinresidues300-400)ofthehumanLPIN1protein.[Swiss-Prot#Q14693].
TheLipinfamilyofnuclearproteinscontainsthreemembers:Lipin-1,Lipin-2andLipin-3,allofwhichcontainanuclearsignalsequence,ahighlyconservedamino-terminal(NLIP)domainandacarboxy-terminal(CLIP)domain.LPIN1(Lipin-1)iscrucialfornormalADIposetissuedevelopmentandmetabolism.LPIN1selectivelyactivatesasubsetofPGC-1átargetpathways,includingfattyacidoxidationandmitochondrialoxidativephosphorylationbyinducingexpressionofthenuclearreceptorPPARá.LPIN1alsoinactivatesthelipogenicprogramandsuppressescirculatinglipidlevels.AnabundanceofLPIN1promotesfataccumulationandinsulinsensitivity,whereasadeficiencyinLPIN1maydeternormaladiposetissuedevelopment,resultingininsulinresistanceandlipodystrophy,aheterogeneousgroupofdisorderscharacterizedbylossofbodyfat,fattyliver,hypertriglyceridemiaandinsulinresistance.
Image:LPIN1stainingofmousepancreastissue.
