Type:GoatIgG
Applications:ICC;WB;IP;E
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Purified,NS0-derived,recombinanthumanBoneMorphogeneticProtein1/ProcollagenC-Proteinase(rhBMP-1/PCP;aa121-730).
Thereareatleast20structurallyandfunctionallyrelatedBMPs,whicharemembersoftheTGF-betasuperfamily.BMPswereoriginallyidentifiedasproteinregulatorsofcartilageandboneformation.Theyarealsoinvolvedinembryogenesisandmorphogenesisofvarioustissuesandorgans.BMPsregulatethegrowth,differentiation,chemotaxisandapoptosisofvariouscelltypes,includingmesenchymalcells,epithelialcells,hematopoieticcellsandneuronalcells.SimilartootherTGF-betafamilyproteins,BMPsarehighlyconservedacrossanimalspecies.
BMP1isamemberoftheastacinfamilyofmetalloproteinases.TheastacinfamilyincludesBMP1,astacin,meprinAandB,tolloid-likeproteins,andchoriolysin.BMP1isinvolvedinextracellularmatrix(ECM)formation,suggestingthatafunctionallinkmayexistbetweenastacinmetalloproteinases,growthfactors,andcelldifferentiationandpatternformationduringdevelopment.ThenamePCPreflectsthisenzyme’sinvolvementinthecollagendepositionofgrowingbone.TheenzymesknownastheprocollagenCandNproteinases(PCPandPNP)areinvolvedintheprocessingoffibrillarprocollagenprecursorstomaturecollagens,whichisanessentialrequirementforfibrilformation.PCPcleavestheC-terminusfromprocollagen,toallowtheformationofmature,triplehelicalcollagen.TheN-terminusiscleavedbytheprocollagenN-proteinase(PNPorADAM-TS2).DefectsinPNPhavebeenlinkedtotheskindisorderdermatosparaxis,anddefectsinBMP1arethoughttoleadtoaberrantcollagenprocessing,andconnectivetissuedisorders.
