Type:GoatIgG
Applications:E;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:PeptidewithsequenceC-KDERFQLEEFS,fromtheinternalregionoftheproteinsequenceaccordingtoNP_660339.1.
Celladhesionmolecule4,CADM4,Immunoglobulinsuperfamilymember4C,IGSF4CorNECL-4. AnimmunohistochemicalstudyrevealsthatCADM4isexpressedatthecell-cellattachmentsitesintherenaltubules,thetransitionalepitheliaofthebladder,andtheglandularepitheliaoftheprostate.
Image:CADM4(Dilution:2.5μg/ml)stainingofparaffinembeddedHumanThymus.SteamedantigenretrievalwithcitratebufferpH6,AP-staining.
CADM4isalso inthetelencephalicwall,whereasitbecomesratherconfinedtothesubplate,thecorticalplateandthesubventricularzoneduringdevelopment. Itgraduallydecreasesafterbirthanddisappearsinadulthood. Itremains atlowlevelsthroughoutembryonicstage.Thesespatiotemporalpatternsoftheexpressionsuggestthat CADM4playscrucialrolesinthedevelopmentofbothtelencephalonandcerebellum.CADMisectopicallyexpressedinadultT-cellleukemia(ATL)cells,providingnotonlyadiagnosticMarkerforATL,butalsoapossIBLetherapeutictargetagainstitsinvasion.
