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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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商品描述
Type:GoatIgG
Applications:IHC;WB;E
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:RecombinanthumanTRAILR3extracellulardomain
TRAILbindsatleastfivedifferentreceptors:TRAILR1(DR4),R2(DR5),R3(DcR1),R4(DcR2),andosteoprotegerin(OPG).TRAILreceptorsallexhibitcysteine-richrepeatscharacteristicoftheTNFreceptorsuperfamily.TRAILR1andR2aretype1transmembraneproteinswithintracellulardeathdomains(DD)and,subsequently,havetheABIlitytomediateTRAIL-inducedapoptosis..TRAILR3ismembrane-associatedviaGPIlinkage.
Thisreceptorcanbeactivatedbytumornecrosisfactorrelatedapoptosisinducingligand(TNFSF10/TRAIL/APO2L),andtransducesapoptosissignal.StudieswithFADDdeficientmicesuggestedthatFADD,adeathdomaincontainingadaptorprotein,isrequiredfortheapoptosismediatedbythisprotein.
