Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllGDNFpromotesthesurvivalanddifferentiationofdopaminergicneuronsinculture,andisabletopreventapoptosisofmotorneuronsinducedbyaxotomy.Theencodedproteinisprocessedtoamaturesecretedformthatexistsasahomodimer.ThematureformoftheproteinisaligandfortheproductoftheRET(rearrangedduringtransfection)protooncogene.InadditiontothetranscriptencodingGDNF,twoadditionalalternativetranscriptsencodingdistinctproteins,referredtoasastrocyte-derivedtrophicfactors,havealsobeendescribed.MutationsinthisgenemaybeassociatedwithHirschsprungdisease.GDNFenhancessurvivalandmorphologicaldifferentiationofdopaminergicneuronsandincreasestheirhigh-affinitydopamineuptake.
Note:ThishGDNFisfullyBIOLOGicallyactivewhencomparedtoastandard.TheED50,calculatedbythedose-dependentdopamineuptakeinratmesencephaliccultures,wasfoundtobe4-8ng/ml.
