TherecombinantST2comprisesa310aminoacidfragment(19-328)correspondingtothe
solubleST2codingsequenceandisexpressedinE.coliwithanamino-terminalhexahistidine
tag.
TheST2geneisamemberoftheIL-1receptorfamily,encodingatransmembraneproteinwitha
structuresimilartoIL-1R1.Asolubleformoftheprotein(ST2)isproducedfromthesamegene
byalternativesplicingandisreportedtobeexpressedinseveralcelltypesincludingfibroblasts
andmastcells.SolubleST2hasbeenreportedtoactasanegativeregulatorofTh2cytokine
productionandelavatedlevelshavebeenreportedinseveraldiseasestatesandconditions
includingasthma,sepsis,andmyocardialinfarction.
Format:liquid
Concentration:0.15mg/mL
Purity:>95%bySDS-PAGE
Storage:Theproteinisstableuntiltheexpirydatewhenstoredat-70°C.Repeatedfreezingand
thawingshouldbeavoided.
