Interleukin-6(IL-6)isacytokineofapproximately26kDathatissynthesizedbyT-cells,macrophages,B-cells,fibroblasts,endothelialcells,andepithelialcells.IL-6actsinbothpro-inflammatoryandanti-inflammatoryways.Whenreleasedsystemicallyitstimulatesthelivertoproduceproteins,suchasC-reactiveproteinandfibrin,whichareresponsIBLefortheacute-phaseresponse.Besidesthesystemicacutephasereaction,IL-6isassociatedwithseveralacuteandchronicinflammatorydiseases,includingrheumatoidarthritis,acutepan-creatitis,viralandbacterialmeningitis,andAlzheimer’sdisease.However,IL-6canalsodownregulatetheinflammatoryreactionbysuppressingthepro-inflammatorycytokinesIL-1andTNF,andprotectagainstlungdamageandsepticshock.
Species:mouse
SampleType: serum,plasma,cellculturesupernates
SampleSize:50uL
StandardCurveRange: 0.008-0.5ng/mL
Sensitivity: 0.008ng/mL
AssayLength: <5hours
