T1/ST2(alsoknownasIL-1R4orIL-33Ra)isatransmembraneglycoproteinexpressedonmastcellsandTh2cells.ItisaselectiveMarkerforbothmurineandhumanTh2lymphocytesandplaysaroleinregulatinginflammatoryresponses.IL-33isarecentlyidentifiedmemberoftheIL-1familyofcytokinesandisinvolvedinTh2mediatedimmuneresponses.IL-33mediatesitsBIOLOGicaleffectsviaT1/ST2binding.TherolesofIL-33andT1/ST2(IL-33Ra)havebeeninvestigatedinmanyimmuneresponsessuchasallergy,asthma,rheumatoidarthritisandosteoarthritis.
Ratanti-MouseT1/ST2PE-conjugatedmAb
Clone:DJ8
IgSubclass:IgG1(lightchainnotisotyped)
Form:TheR-phycoerthrinfreeBovineSerumAlbumin(BSA)andwith0.1%sodiumazideasaperservativeandpurifiedoverproteinG-sepharose.ThecharacteristicsofeachlotaretestedbyFACSanalysiswithbone marrowderivedmastcells.
Specificity:ThisclonerecognizesthemembraneanchoredmurineT1MproteinonthesurfaceofThelper 2cellsandmastcells.T1MappearsonfetalbloodderivedmastcellProgenitorsbeforethey expresstheFceRI,onIL-3-dependentbonemarrowderivedmastcellsandonmatureperitoneal mastcells.TheantibodydetectsT1Sproteinconsistingonlyoftheextracellularportionof theprotein,whichissecretedfromgrowthfactorandproinflammatorycytokine-stimulated murinefibroblasts.
Immunogen:EukarioticallyexpressedfusionproteinofmouseT1ectodomainandhumanimmunoglobulin Fcdomain.
How_To_Use:
ThisantibodyallowstheidentificationandpurificationofmurineThelper2cellsandallforms ofmurinemastcells.
Applications
- Flowcytometry
- immunoprecipitation
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