Lumican(LUM)isthemajorkeratansulfateproteoglycanofthecorneaanditbindscollagenfibrils.Innoncornealtissues,lumicanispresentasalowornonsulfatedglycoproteinandhasbeenfoundintheaorta,cartilage,liver,skeletalmuscle,kidney,pancreas,brain,placentaandlung.Complicationsofthecorneahavebeenconfirmedusinglumican-nullmice.Thesemiceexhibitcornealopacity,skinfragility,andimpairedcollagenfibrillogenesis.Morerecentstudiesshowlumicanhasanintegralroleincellmigration,adhesionandproliferation.Theexpressionoflumicanhasalsobeenexaminedinbreast,pancreaticandcolorectalcancer.Theaffectoflumicandependsonthetypeofcancerasithasbeenshowntohavebothapositiveandnegativeaffectontumorgrowth.
RelatedTerms/Symbols
- LUM
- LDC
- SLRR2D
- P51884
- Lumicanproteoglycan
- majorkeratansulfateproteoglycan
Clone:Lum-1
Host:Mouse
Isotype:IgM
Purity:Affinitypurifiedonthiophiliccolumn
Form:Liquid,1mL/vial
Concentration:0.1mg/mL
Storage: -20°C.
Specificity:ThisLumicanantibodyrecognisesaproteinepitopeinlumicanderivedfromhuman,bovine,porcine&mousetissues.
How_To_Use:
Applications
- WesternBlot:recommendeddilution0.2mg/mL
- IHC
TechnicalNotes
ThisepitopeisbestrecognizedafterkeratanaseandkeratanaseIItreatment/digestion
ofsection(IHC)ortissueextracts(forWesternanalyses).InsomeIHCtissueanalyses,
chondroitinasetreatmentmayalsobeused,asthissecondenzymetreatmentfacilitates
antibodypenetrationintothetissue.
MD Bioproducts牛I型胶原蛋白（胶原蛋白）目录编号： 8052013数量/尺寸： 30毫克北美：1-888-USMDBIO国际：+ 41-44 986 2628或您可以使用我们的在线表格订购有疑问或需要批量吗？没问题，只问。从牛腱中纯化的I型牛胶原蛋白（Atelocollagen）总览数据/规格文学/支持如何使用相关产品概述： I型胶原蛋白是最丰富的胶原蛋白，存在于结缔组织中，包括腱，韧带，真皮和血管。它是细胞外基质（ECM）拉伸强度的主要成分和主要决定因素。它被广泛用作组织培养表面上的薄层，以增强各种细胞（包括内皮细胞，成纤维细胞，肝细胞，上皮细胞等）的附着和增殖。此外，胶原蛋白I可以自组装成3-D超分子凝胶体外，使其成为理想的生物支架，可促进更多体内样细胞的形态和功能。 符号/相关术语： COL1A1COL1A2成骨不全
