β2-Microglobulin(β2M)isasmallserumproteinthatconstitutesthelightchainofthemajorhistocompatibilityclassIhumanleukocyteantigen(HLAclassI),anintegralmembraneproteininvolvedintheimmuneresponse.Theproteinis99aminoacidresiduesinlengthandhasmolecularmassof12kDa.β2MisreleasedfromthecellsurfaceofHLAclassIintotheserumandcarriedtothekidneysfordegradationandsecretion.Inchronicrenalfailure,β2Maccumulatesasinsolubleamyloidaggregatesandcausesarthralgias,destructiveosteoarthropathies,carpaltunnelsyndromeanddialysis-relatedamyloidosis.Elevatedserumβ2Mlevelsareassociatedwithpoorprognosisinmultiplemyelomaandlymphoma.
Species:human
SampleType: serum,plasma,cellculturesupernate
SampleSize:50uL
StandardCurveRange: 0-200ng/mL
Sensitivity: 0.7ng/mL
AssayLength: 3hours40min