ProductDescription
Haptoglobinisaserumproteinthatconsistsoftwoalphaandtwobetachainsconnectedbydisulfidebridges.Thealphaandbetachainsarecharacterizedbymolecularweightsof~10kDaand~40kDarespectively.Itactsasahemoglobinscavengerandhasbeenassociatedwithproteaseinhibitoryactivity.Itisapositiveacutephasereactant,thelevelsofwhichincreasesignificantlyinratsinresponsetoinflammation,tissueinjuryordisease.HaptoglobinispurifiedatLifeDiagnosticsusingacombinationofaffinity,gelfiltrationandion-exchangechromatographysteps.
Life Diagnostics免疫毒性ELISA试剂盒抗KLH、抗SRBC、抗破伤风类毒素、抗DNP和抗TNP的IgM和IgG作为免疫毒性的生物标志物。Life Diagnostics为小鼠、大鼠、鸡和猴子的这些生物标记物制造ELISA试剂盒。在临床前研究中,给动物注射候选药物时,用抗原如KLH进行免疫。在第7天或第21天采集血清,测定抗KLH-IgM和IgG水平,并与未接触药物的对照组进行比较。治疗组抗KLH水平的降低提供了免疫抑制的证据。