Product Description

Creatine kinase (CK) is a key metabolic enzyme. It is a dimer of two subunits, each with molecular weights of approximately 43 kDa. Two different subunits are expressed, M and B. The CK holoenzyme exists as MM and BB homodimers and an MB heterodimer. The MM and BB isoforms are expressed primarily in skeletal muscle and brain respectively while both MB and MM are expressed in heart. CK-MM was purified from skeletal muscle using affinity chromatography. It has not been evaluated for enzyme activity.

Life Diagnostics免疫毒性ELISA试剂盒抗KLH、抗SRBC、抗破伤风类毒素、抗DNP和抗TNP的IgM和IgG作为免疫毒性的生物标志物。Life Diagnostics为小鼠、大鼠、鸡和猴子的这些生物标记物制造ELISA试剂盒。在临床前研究中，给动物注射候选药物时，用抗原如KLH进行免疫。在第7天或第21天采集血清，测定抗KLH-IgM和IgG水平，并与未接触药物的对照组进行比较。治疗组抗KLH水平的降低提供了免疫抑制的证据。