Product Description
The polypeptide chain of human LRG1 (leucine rich alpha 2 glycoprotein-1) has a molecular weight of ~34,500 Da. It is N-glycosylated t multiple sites and migrates on reducing SDS PAGE gels as a major band of ~50 kDa. It is an acute phase protein that is upregulated in the serum of patients suffering from various diseases including ovarian cancer, Kawasaki disease and rheumatoid arthritis.
Life Diagnostics免疫毒性ELISA试剂盒抗KLH、抗SRBC、抗破伤风类毒素、抗DNP和抗TNP的IgM和IgG作为免疫毒性的生物标志物。Life Diagnostics为小鼠、大鼠、鸡和猴子的这些生物标记物制造ELISA试剂盒。在临床前研究中,给动物注射候选药物时,用抗原如KLH进行免疫。在第7天或第21天采集血清,测定抗KLH-IgM和IgG水平,并与未接触药物的对照组进行比较。治疗组抗KLH水平的降低提供了免疫抑制的证据。