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商品描述
Sclerostin,alsoknownasSOST,isamemberoftheCerberus/DANfamilyofBMPantagoNISTs.SOSTisasecretedglycoproteinwithaC-terminalcysteineknot-like(CTCK)domain.ItshowssequencesimilaritytotheDAN(differentialscreening-selectedgeneaberrativeinneuroblastoma)familyofbonemorphogeneticprotein(BMP)antagonists.SOSTisproducedbytheosteocyteandhasanti-anaboliceffectsonboneformation.ItisanegativeregulatorofbonegrowththatactsthroughinhibitionofWntsignalingandboneformation.
| Source | HEK293 |
| Names | SOST,UNQ2976,PRO7455,PRO7476 |
| Accession# | Q9BQB4 |
| Formulation | Suppliedasa0.2μMfilteredsolutionof20mMTris,250mMNaCl,pH8.0 |
| Shipping | Theproductisshippedondryice/icepacks. |
| Storage | Storeat<-20°C,stablefor6monthsafterreceipt. Pleaseminimizefreeze-thawcycles. |
| Purity | Greaterthan95%asdeterminedbySEC-HPLCandreducingSDS-PAGE. |
| Endotoxin | Lessthan0.1ng/µg(1IEU/µg). |
| AminoAcidSequence | QGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAYHHHHHH |
