| MolecularWeight: | 429.9g/mol |
| MolecularFormula: | C22H23N3O4•HCl |
| CASNumber: | 183319-69-9 |
| Solubility: | SolubleinDMSOat18mg/mLwithwarming;verypoorlysolubleinethanol |
| Purity: | ≥99% |
| Storage: | -20C |
| Applications: | Anti-neoplastic |
SignalWord PrecautionaryStatement P264 P301+P312 P501 | Warning Washskinthoroughlyafterhandling IFSWALLOWED:CallaPOISONCENTERordoctor/physicianifyoufeelunwell. Disposeofcontents/containertoanapprovedwastedisposalplant |
2.3Otherhazards
None
3.COMPOSITION/INFORMATIONONINGREDIENTS
3.1Substances
MolecularFormula:C₂₉H₃₁N₇O.CH₄SO₃
MolecularWeight:429.9g/mol
CASNo:183319-69-9
4.FIRSTAIDMEASURES
4.1Descriptionoffirstaidmeasures
Eyecontact
Checkforandremovecontactlensesandflushwithcopiousamountsofwater;assureadequateflushingbyseparatingtheeyelidswithfingers;callaphysician
SkinContact
Flushwithcopiousamountsofwater;removecontaminatedclothingandshoes;callaphysician
Inhalation
Ifinhaled,removetofreshair;ifbreathingisdifficult,giveoxygen;ifbreathingstops,giveartificialrespiration
Ingestion
Ifswallowed,washoutmouthwithcopiousamountsofwater;callaphysician
4.2Mostimportantsymptomsandeffects,bothacuteanddelayed
Noinformationavailable
4.3Indicationofanyimmediatemedicalattentionandspecialtreatmentneeded.
Noinformationavailable
5.FIREFIGHTINGMEASURES
5.1Extinguishingmedia
Suitableextinguishingmedia
Waterspray,carbondioxide,drychemicalpowderorfoam
5.2Specialhazardsarisingfromthesubstanceormixture
Noinformationavailable
5.3Adviceforfirefighters
Wearself-containedbreathingapparatusandprotectiveclothingtopreventcontactwithskinandeyes.
6.ACCIDENTALRELEASEMEASURES
6.1Personalprecautions,protectiveequipmentandemergencyprocedures
Usefullpersonalprotectiveequipment.Evacuatepersonneltosafeareas.
6.2Environmentalprecautions
Preventfurtherleakageorspillage.Preventproductfromenteringdrain.
6.3Methodsandmaterialforcontainmentandcleaningup
Absorbsolutionswithfinely-powderedliquid-bindingmaterial(diatomite,universalbinders);decontaminatesurfacesandequipmentbyscrubbingwithalcohol;disposeofcontaminatedmaterialaccordingtoSection13
7.HANDLINGANDSTORAGE
7.1Precautionsforsafehandling
Avoidskin/eyecontact.Useprotectiveequipmentasneeded.Washcontaminatedclothingbeforereuse.
7.2Conditionsforsafestorage,includinganyincompatibilities
Keepcontainertightlyclosedinacool,well-ventedplace.Storeat-20˚C.
7.3Specificenduse(s)
Nodataavailable.
8.EXPOSURECONTROLS/PERSONALINFORMATION
8.1ControlParameters
Thisproductcontainsnohazardousmaterialswithoccupationalexposurelimits.
8.2Exposurecontrols
Engineeringcontrols
Provideshowerandeyewashstation
Personalprotectiveequipment
EyeProtection | Wearsafetygoggles |
SkinProtection | Wearprotectiveclothing |
HandProtection | Wearprotectivegloves |
Respiratoryprotection | WearNIOSH/MSHAapprovedrespirators |
9.PHYSICALANDCHEMICALPROPERTIES
9.1Informationonbasicphysicalandchemicalproperties
Appearance | Solid |
pH | Nodataavailable |
Meltingpoint | Nodataavailable |
Freezingpoint | Nodataavailable |
Boilingpoint | Nodataavailable |
Density | Nodataavailable |
Watersolubility | Verypoorlysoluble |
9.2Othersafetyinformation
Nodataavailable.
10.STABILITYANDREACTIVITY
10.1Reactivity
Nodataavailable
10.2Chemicalstability
Stableunderrecommendedstorageconditions.
10.3Possibilityofhazardousreactions
Nodataavailable.
10.4Conditionstoavoid
Protectfromlightandheat
10.5IncompatIBLematerials
strongoxidizingagents
10.6Hazardousdecompositionproducts
Thermaldecompositionmayproducetoxicgasessuchascarbonmonoxide,carbondioxide,andnitrogenoxides
11.TOXICOLOGICALINFORMATION
11.1Informationontoxicologicaleffects
Toxicologicaleffectsonthisproducthavenotbeenthoroughlystudied.
12.ECOLOGICALINFORMATION
12.1Toxicity
Avoidreleaseintoenvironment
12.2Persistenceanddegradability
Nodataavailable
12.3.Bioaccumulativepotential
Nodataavailable
12.4Mobilityinsoil
Nodataavailable
12.5ResultsofPBTandvPvBassessment
Nodataavailable
12.6Otheradverseeffects
Nodataavailable
13.DISPOSALINFORMATION
13.1Wastetreatmentmethods
Disposeinaccordancewithlocal,state,andfederalregulations.
14.TRANSPORTINFORMATION
DOT:
Propershippingname:none
Non-Hazardousfortransport:thissubstanceisconsideredtobenon-hazardousfortransport
IATA:
Propershippingname:none
Non-Hazardousfortransport:thissubstanceisconsideredtobenon-hazardousfortransport
IMDG:
Propershippingname:none
Non-Hazardousfortransport:thissubstanceisconsideredtobenon-hazardousfortransport
15.REGULATORYINFORMATION
EURiskandSafetyphrases:
R22:Harmfulifswallowed
S22:Donotbreathedust
S24/25:Avoidcontactwithskinandeyes
S26:Incaseofcontactwitheyes,rinseimmediatelywithplentyofwaterandseekmedicaladvice
S28:aftercontactwithskin,washimmediatelywithplentyofwater
S36/37/39:Wearsuitableprotectiveclothing,glovesandeye/faceprotection
16.OTHERINFORMATION
WangY,YuanJL,ZhangYT,MaJJ,XuP,etal.(2013)InhibitionofBothEGFRandIGF1RSensitizedProstateCancerCellstoRADIationbySynergisticSuppressionofDNAHomologousRecombinationRepair.PLoSONE8(8):e68784.doi:10.1371/journal.pone.0068784
