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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Methionineaminopeptidase1,METAP,alsonamedMAP1,MetAP1,PeptidaseM1,isamemberoftheM24familyofmetalloproteases.METAPsplayacentralroleforproteinmaturationastheyremovetheinitiatorMetresiduefromnewlysynthesizedproteinsandareessentialforcellgrowth.ThreeMETAPgenes(METAP1,METAP2andMAP1D)havebeenidentifiedinthehumangenome.METAP1andMETAP2havedifferentsubstratespecificityduetothedifferencesinbothsizeandshapeoftheactivesites.METAP1playsanimportantroleinG(2)/Mphaseregulationofthecellcycleandmayserveasapromisingtargetforthediscoveryanddevelopmentofnewanticanceragents.Fumagillin,anaturalcompound,covalentlymodifiesanactiveHisresidueofMETAP2andpreventsthevascularizationandmetasisoftumors.
| Source | E.coli |
| Names | MethionineAminopeptidase,MAP,PeptidaseM,map |
| Accession# | P0AE18 |
| Formulation | Suppliedasa0.2μMfilteredsolutionof20mMTris-HCl,100mMNaCl,50%Glycerol,pH8.0 |
| Shipping | Theproductisshippedondryice/icepacks. |
| Storage | Storeat<-20°C,stablefor6monthsafterreceipt. Pleaseminimizefreeze-thawcycles. |
| Purity | Greaterthan95%asdeterminedbySEC-HPLCandreducingSDS-PAGE. |
| Endotoxin | Lessthan0.1ng/μg(1IEU/μg). |
| AminoAcidSequence | MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDELEHHHHHH |
