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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Sheep antibody to rh NTN (Neurturin): whole serum/S-010-100/100 µl
商品描述
| Description | Neurturin(NTN)isamemberoftheGDNFfamilyofneurotrophicfactors.Thisproteinisapotentsurvivalfactorforseveralpopulationsofcentralandperipheralneuronsinmatureanddevelopingrodents.FUNCTION:Supportsthesurvivalofsympatheticneuronsinculture.MayregulatethedevelopmentandmaintenanceoftheCNS.Mightcontrolthesizeofnon-neuronalcellpopulationsuchashaemopoieticcells.SUBUNIT:Homodimer;disulfide-linked.SUBCELLULARLOCATION:Secretedprotein.DISEASE:DefectsinNRTNareacauseofHirschsprungdisease(HSCR).InassociationwithmutationsofRETgene,andpossIBLywithotherloci,defectsinNRTNareinvolvedinHirschsprungdisease.Thisgeneticdisorderofneuralcrestdevelopmentischaracterizedbytheabsenceofintramuralganglioncellsinthehindgut,oftenresultinginintestinalobstruction.SIMILARITY:BelongstotheTGF-betafamily.GDNFsubfamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | RecombinanthumanNeurturin(rhNTN) |
| OtherNames | Neurturin;NRTN; |
| Accession | NRTN_HUMAN |
| Producedin | Sheep |
| Purity | Wholeserum |
| Applications | IHC,WB,immunoblot,1-siteELISA.Recommendedtobeusedatadilutionof1:2000-3000forimmunohistochemistryandWesternblot,1:2000to1:4000forELISA.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | DotblotshowsnocrossreactivitytoGDNF. |
| Cross-reactivity | Thisantibodyisknowntoreactwithhuman,mouseandrat.Notyettestedagainstotherspecies. |
| Blastit | IfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | 1.Kotzbauer,etal.(1996)Nature.384(6608):467-70 2.Golden,etal.(1998),JCompNeurol398,139-50 3.Xian,etal.(1999),BrainRes.835(2):247-58 |
