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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Rabbit polyclonal antibody to Tyrosine Kinase Receptor A [TrkA] (342-361): Affinity purified/R-1362-100/100 µg
商品描述
| Description | TrkAisamemberoftheneurotrophictyrosinekinasereceptorfamily.Itisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkAisrequiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).TrkAleadstocelldifferentiationsandmayplayaroleinspecifyingsensoryneuronsubtypes.Ithasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.SUBCELLULARLOCATION:Cellmembrane;single-passtypeImembraneprotein.EndocytosedtotheendosomesupontreatmentofcellswithNGF.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.BothisoformshavesimilarBIOLOGicalproperties.TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells.IsoformTrkA-Iisfoundinnon-neuronaltissues.MutationsinTrkAhavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutalatingbehaviour,mentalretardationandcancer. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | AsyntheticpeptidecorrespondingtoasequenceinthemiddleregionofhumanTrkA(342-361aa)RHGCLRLNQPTHVNNGNYTL).Thissequenceisidenticaltotherelatedratandmousesequencesaswell. |
| Sequence | RHGCLRLNQPTHVNNGNYTL |
| AntigenLocation | WithintheIg-likeC2-type2Domainspanningtwoglycosylationsites;epitopelieswithintheextracellularregionoftheprotein(33-423aa)within100aminoacidsofitsentryintothetransmembranedomain(aa424-439)[UniprotP04629(NTRK1_HUMAN) |
| AntibodyType | Antiserum |
| Isotype | IgG |
| OtherNames | Tropomyosin-relatedkinasereceptor,Highaffinitynervegrowthfactorreceptor,Neurotrophictyrosinekinasereceptortype1,TRK1transformingtyrosinekinaseprotein,p140-TrkA,Trk-A,GENENAME:NTRK1,TRK. |
| Accession | P04629NTRK1_HUMAN; |
| Producedin | Rabbit |
| Purity | Affinitypurified |
| Applications | WesternBlotting(WB).Aconcentrationof0.1-0.5µg/mlisrecommendedforWB.HumanTrkA(isoformTrkA-II)hasapredictedlengthof796aminoacidsandMWof87kDa.Aconcentrationof0.5-1.0µg/mlisrecommendedtodetecttheproteininformalinfixedandparaffinembeddedtissues.Heatmediatedantigenretrievalisrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWBandIHCagainsttheantigen. |
| AntibodyAgainst | TyrosineKinaseReceptorA,TrkA |
| Cross-reactivity | Human;rat;predictedtoreactwithmouseduetosequencehomology; |
| BlastURL | Clickhere |
| Form | Lyophilizedwith5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3addedaspreservative |
| Appearance | Lyophilizedwhitepowder |
| Reconstitution | Reconstitutein100µlofsteriledistilledwatertoachieveanantibodyconcentrationof1mg/ml.Centrifugetoremoveanyinsolublematerial. |
| Storage | Atleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
