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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Rabbit antibody to Nociceptin (139-151): whole serum/R-105-100/100 µl
商品描述
| Description | FUNCTION:Nociceptinistheligandoftheopioidreceptor-likereceptor(OPRL1).Itmayactasatransmitterinthebrainbymodulatingnociceptiveandlocomotorbehavior.Maybeinvolvedinneuronaldifferentiationanddevelopment.SUBCELLULARLOCATION:Secretedprotein.TISSUESPECIFICITY:Expressedpredominantlyinthespinalcordandbrain,beingmoreabundantinthehypothalamusandstriatum.Alsofoundinsmallamountsinovary.PTM:Specificenzymaticcleavagesatpairedbasicresiduesprobablyyieldotheractivepeptidesbesidesnociceptin.PTM:TheN-terminaldomaincontains6conservedcysteinesthoughttobeinvolvedindisulfidebondingand/orprocessing.SIMILARITY:Belongstotheopioidneuropeptideprecursorfamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(C-TGARKSARKLANQ)aspartofratNociceptinpeptide(aa:139-151)conjugatedtodiphtheriatoxoid |
| OtherNames | Therearenosynonymsforthispeptide;howevertheprecursorproteincontains:Neuropeptide1;Nociceptin(OrphaninFQ;PPNOC;ORL1receptoragoNIST);Neuropeptide2 |
| Accession | PNOC_RAT |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC,1-siteELISA.Adilutionof1:1000to1:3000isrecommendedforbothapplications.Thisantibodymayalsobeusedforstainingofnervefibresinguineapigmyentericplexus.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Specificityhasbeentestedbytheuseofdifferentpeptidesincludingenkephalin,dynorphinandendorphinforabsorptioninimmunihistochemistry. |
| Cross-reactivity | Thisantibodyisknowntocrossreactwithguineapigandrat. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| References | Darlandetal.(1998)TrendsNeurosci.21:215-221 |
