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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Mouse monoclonal antibody to rh c-FOS: Affinity purified/M-1752-100/100 µg
商品描述
| Description | FUNCTION:Nuclearphosphoproteinwhichformsatightbutnon-covalentlylinkedcomplexwiththeJUN/AP-1transcriptionfactor.Intheheterodimer,FOSandJUN/AP-1basicregionseachseemstointeractwithsymmetricalDNAhalfsites.OnTGF-betaactivation,formsamultimericSMAD3/SMAD4/JUN/FOScomplexattheAP1/SMAD-bindingsitetoregulateTGF-beta-mediatedsignaling.Hasacriticalfunctioninregulatingthedevelopmentofcellsdestinedtoformandmaintaintheskeleton.Itisthoughttohaveanimportantroleinsignaltransduction,cellproliferationanddifferentiation.Ingrowingcells,activatesphospholipidsynthesis,possIBLybyactivatingCDS1andPI4K2A.ThisactivityrequiresTyr-dephosphorylationandassociationwiththeendoplasmicreticulum.SUBUNIT:Heterodimer.InteractswithDSIPI;thisinteractioninhibitsthebindingofactiveAP1toitstargetDNA.InteractswithMAFB.SUBCELLULARLOCATION:Nucleus.INDUCTION:C-fosexpressionincreasesuponavarietyofstimuli,includinggrowthfactors,cytokines,neurotransmitters,polypeptidehormones,stressandcellinjury.SIMILARITY:BelongstothebZIPfamily.Fossubfamily.SIMILARITY:Contains1bZIPdomain(Ref:uniprot.org). |
| BatchNo. | Seeproductlabel. |
| Unitsize | 100µg |
| Antigen | Fulllength,E.coli-derivedrecombinanthumanc-FOSprotein. |
| AntibodyType | Monoclonal |
| Isotype | IgG1 |
| OtherNames | Cellularoncogenefos;G0/G1switchregulatoryprotein7;cFOS |
| Accession | FOS_HUMAN |
| Producedin | Mouse. |
| Purity | Affinitypurified. |
| Applications | Immunohistochemistry(IHC)andimmunocytochemistry(ICC):1-2µg/mL.Thisantibodyhasbeenshowntoworkon4%PFAfixedmousebrainsections. Westernblotting(WB):0.5-1.0µg/mL.Thisantibodydetectsbandsbetween50-65kDa,whichonlyappearinstimulatedcells. Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Human. |
| Cross-reactivity | Horse,cow,pig,chicken,rat,mouse. |
| BlastURL | Clickhere |
| Form | Lyophilizedfromasolutioncontaining3%trehaloseinPBS,pH7.4,withoutpreservatives. |
| Reconstitution | Reconstitutewith100µLsterile-filtered,ultrapurewater,toachieveanantibodyconcentrationof1mg/mL.Centrifugebrieflytoremoveanyinsolublematerial. |
| Storage | Storelyophilised,unopenedvialat2-8°Corlower.Afterreconstitution,preparealiquotsandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchaseifunopenedandstoredasindicated. |
| GeneralReferences | VanstrAATenetal(1983)Proc.Natl.Acad.Sci.80:3183(Originalmolecularc-fossequencepaper) MinsonJ.etal.(1994)BrainRes.646:44-52(EarlyIHClocalizationpaper) |
